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KMID : 0043320110340060971
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Archives of Pharmacal Research
2011 Volume.34 No. 6 p.971 ~ p.978
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Rhododendrin, an analgesic/anti-inflammatory arylbutanoid glycoside, from the leaves of Rhododendron aureum
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Kim Myung-Hoe
Nugroho Agung
Choi Jong-Won
Park Jong-Hee
Park Hee-Juhn
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Abstract
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To identify an analgesic/anti-inflammatory component from the leaves of Rhododendron aureum (Ericaceae), phytochemical isolation and pharmacological assays (writhing assays and vascular permeability assay for analgesic action in mice; carrageenan-induced paw edemaand TPA-induced ear edema assays of anti-inflammatory action in rats) were performed. Four compounds were isolated from the active fraction (BuOH fraction) by silica gel column chromatography and identified as (?)-rhododendrol, (?)-rhododendrin, avicularin and hyperoside by spectroscopic methods. Rhododendrin, the main compound of the BuOH fraction, exhibited significant analgesic actions in mice and anti-inflammatory actions in rats. This compound accounted for 3.1% of the MeOH extract and 0.48% of dried leaves, respectively, on HPLC analysis. These results suggest that rhododendrin is the major biologically active substance in the leaves of R. aureum with analgesic/anti-inflammatory activity.
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KEYWORD
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Rhododendron aureum, Ericaceae, Rhododendrin, Antinociceptive, Anti-inflammatory
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